Python Job: Student Internship for “eTox Data Integration and

At Roche, 80,000 people across 150 countries are pushing back the frontiers of healthcare.

We believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.

We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

Pharmaceutical Sciences (PS) is a global function within Roche Pharma Research and Early Development (pRED). As a team member in Predictive Modeling and Data Analytics (PMDA) chapter of PS, you will work in close collaboration with scientists in pRED, using state-of-the-art bioinformatics and biostatistics tools and methods.

Repeated dose toxicity (RDT) studies in laboratory animals is one of the pillars of pharmaceutical safety evaluations. Over the past decades, pharmaceutical companies have conducted a large number of high-quality in vivo RDT studies for regulatory purposes. These studies are a valuable resource which can be queried directly or further exploited to build predictive models.

The eTox Database was developed as part of a project that had the global aim of compiling the reports from RDT studies donated from participating companies (including Roche), extracting and harmonizing the data therein and storing it in an integrated database. As of May 2016, (version 2016.1), the eTOX consortium has compiled reports from 7156 studies (1855 compounds) resulting in almost 9 million data points. The eTOX database is a highly valuable resource on its own, which can be queried to extract information about any of the RDT studies.

We are seeking an intern pursuing a master’s or PhD degree with expertise in computer science and toxicology to help us explore its applications in forward and reverse translation of drug discovery. The main focus of the intern project is on making the eTox data source accessible and available for further exploration and development of predictive models.

In this position you will:

• Critically explore the current eTox DB structure and available documentation

• Propose an optimal structure for the organization of the eTox RDT studies

• Pre-process data and adjust the annotations to meet internal standards and provide a solid reference for safety-related questions

• Integrate the datasets into an internal database

• Integrate visualization tools to facilitate the eTox DB usage across pRED

• Share gathered knowledge and data with Roche’s advanced analytics and safety communities

Qualifications Required:

• You are currently enrolled in a Master’s program or have completed your studies a maximum of 12 months ago in bioinformatics or related discipline (e.g. computer science, biomedicine, biological sciences, biostatistics).

You have experience and expertise in the following:

• Strong data engineering, visualization, and interpretation skills.

• Strong programming skills in Python

• Good understanding of API and database development and architecture

• Familiarity with toxicology, and in particular repeated dose toxicity studies are preferable

• Background in one of the following domains: computer science, mathematics or statistics, biology, complemented by basic knowledge in the other domains

You have very good interpersonal and communication skills, are able to build good working relationships, and are an outstanding teammate. Your experience and investigative attitude allow you to work independently, to dive deep into database, and to design, perform, and interpret experiments.

All applications need to include a CV, a motivation letter, and 1-2 references.

Start: May 2023

Duration: 9-12 Months

Workload: 100%

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.